Review: Stimulant Augmentation with Antidepressant in Elderly Patients with Major Depressive Disorder

According to the Centers for Disease Control and Prevention (CDC), depression affects about 1%-5% of the general elderly population, 13.5% in elderly who require home healthcare, and 11.5% in older hospital patients” CDC, 2017. Depression in the elderly is accompanied by functional weakening and early death due to suicide and other causes, Symptoms may include sadness; lack of interest, power, and ability to concentrate; insomnia and decreased appetite; and co-disease. Elderly patients have a lower response to antidepressant medications than adult patients.