ANALYSIS OF THE IMPACT OF MINDFULNESS ON QUALITY OF LIFE IN  PATIENTS WITH MULTIPLE SCLEROSIS: SYSTEMATIC REVIEW

Vitória Mallmann Fedeger; Erica Pedri; Rosiane Guetter Mello; Alexandre Leal Laux

doi:10.18535/ijsrm/v9i06.mp02

Abstract

This study aimed to investigate the impact of the mindfulness-based interventions program on the quality of life of patients with Multiple Sclerosis. A systematic review was carried out based on the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes). For an updated perspective on the topic, the selected articles were published from March 2014 to March 2019. Thus, 10 articles were included in the review and were thoroughly compared. A detailed assessment was carried out to measure the impact of the mindfulness protocol both on the general quality of life and on its specific domains. It can be observed that there is some homogeneity of the results regarding the benefits of the practice of mindfulness in the patients’ general quality of life. Moreover, there was greater evidence of the effects of meditative practice on the psychological domain when compared to the physical domain. Hence, the present study considers the mindfulness program a viable tool to address quality of life in patients with Multiple Sclerosis. The lack of Brazilian studies in the area is highlighted. Also, further studies to evaluate the practice of mindfulness continuously, such as cohort studies, are necessary to elucidate the long-term effects of the protocol.

Keywords

MindfulnessMultiple SclerosisQuality of lifeMeditationAwareness

References

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Senders A, Hanes D, Bourdette D, Carson K, Marshall LM, Shinto L. Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial. Mult Scler J. 2018;1–11.Google Scholar ↗
Allen M, Dietz M, Blair KS, Beek M Van, Rees G. mindfulness intervention. 2015;32(44):15601–10.Google Scholar ↗
Mioduszewski O, MacLean H, Poulin PA, Smith AM, Walker LAS. Trait Mindfulness and Wellness in Multiple Sclerosis. Can J Neurol Sci. 2018;45(5):580–2.Google Scholar ↗
Cavalera C, Rovaris M, Mendozzi L, Pugnetti L, Garegnani M, Castelnuovo G, et al. Online meditation training for people with multiple sclerosis: A randomized controlled trial. Mult Scler J. 2019;25(4):610–7.Google Scholar ↗
Pagnini F, Cavalera C, Rovaris M, Mendozzi L, Molinari E, Phillips D, et al. Longitudinal associations between mindfulness and well-being in people with multiple sclerosis. Int J Clin Heal Psychol [Internet]. 2019;19(1):22–30. Available from: http://dx.doi.org/10.1016/j.ijchp.2018.11.003DOI ↗Google Scholar ↗
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Blankespoor RJ, Schellekens MPJ, Vos SH, Speckens AEM, de Jong BA. The Effectiveness of Mindfulness-Based Stress Reduction on Psychological Distress and Cognitive Functioning in Patients with Multiple Sclerosis: a Pilot Study. Mindfulness (N Y). 2017;8(5):1251–8.Google Scholar ↗
Carletto S, Tesio V, Borghi M, Francone D, Scavelli F, Bertino G, et al. The effectiveness of a body-affective mindfulness intervention for multiple sclerosis patients with depressive symptoms: A randomized controlled clinical trial. Front Psychol. 2017;8(NOV):1–13.Google Scholar ↗
Gilbertson RM, Klatt MD. Mindfulness in motion for people with multiple sclerosis: A feasibility study. Int J MS Care. 2017;19(5):225–31.Google Scholar ↗
Simpson R, Mair FS, Mercer SW. Mindfulness-based stress reduction for people with multiple sclerosis - A feasibility randomised controlled trial. BMC Neurol. 2017;17(1):1–12.Google Scholar ↗
Bogosian A, Hughes A, Norton S, Silber E, Moss-Morris R. Potential treatment mechanisms in a mindfulness-based intervention for people with progressive multiple sclerosis. Br J Health Psychol. 2016;Google Scholar ↗
Carletto S, Borghi M, Francone D, Scavelli F, Bertino G, Cavallo M, et al. The efficacy of a Mindfulness Based Intervention for depressive symptoms in patients with Multiple Sclerosis and their caregivers: Study protocol for a randomized controlled clinical trial. BMC Neurol. 2016;Google Scholar ↗
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Kabat-Zinn J. Mindfulness-Based Stress Reduction ( Mbsr ): Standards Of Practice Edited and Revised by: Saki F Santorelli. 1996;(February):1–24.Google Scholar ↗
Kabat-zinn J. An Outpatient Program in Behavioral Medicine for Chronic Pain Patients Based on the Practice of Mindfulness Meditation : Results. 1982;Google Scholar ↗
Baer RA. Mindfulness Training as a Clinical Intervention : 2003;(1998):125–43.Google Scholar ↗
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Willekens B, Perrotta G, Cras P, Cools N. Into the Moment: Does Mindfulness Affect Biological Pathways in Multiple Sclerosis? Front Behav Neurosci. 2018;12(May):1–9.Google Scholar ↗
Pakenham KI, Mawdsley M, Brown FL, Burton NW, Pakenham KI, Mawdsley M, et al. Rehabilitation Psychology People With Multiple Sclerosis Multiple Sclerosis. 2017;Google Scholar ↗
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Turner AP, Knowles LM. Behavioral Interventions in Multiple Sclerosis. 2020;(April):31–5.Google Scholar ↗
Schirda B, Nicholas JA, Prakash RS. Examining trait mindfulness, emotion dysregulation, and quality of life in multiple sclerosis. Heal Psychol. 2015;Google Scholar ↗
Topcu G, Griffiths H, Bale C, Trigg E, Clarke S, Potter K, et al. Psychosocial adjustment to multiple sclerosis diagnosis : A meta-review of systematic reviews. Clin Psychol Rev [Internet]. 2020;82(September):101923. Available from: https://doi.org/10.1016/j.cpr.2020.101923DOI ↗Google Scholar ↗
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[refR-1] Ministério da Saúde. Protocolo Clínico e Diretrizes Terapêuticas Esclerose Múltipla. 2019;Google Scholar ↗

[refR-2] Senders A, Hanes D, Bourdette D, Carson K, Marshall LM, Shinto L. Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial. Mult Scler J. 2018;1–11.Google Scholar ↗

[refR-3] Allen M, Dietz M, Blair KS, Beek M Van, Rees G. mindfulness intervention. 2015;32(44):15601–10.Google Scholar ↗

[refR-4] Mioduszewski O, MacLean H, Poulin PA, Smith AM, Walker LAS. Trait Mindfulness and Wellness in Multiple Sclerosis. Can J Neurol Sci. 2018;45(5):580–2.Google Scholar ↗

[refR-5] Cavalera C, Rovaris M, Mendozzi L, Pugnetti L, Garegnani M, Castelnuovo G, et al. Online meditation training for people with multiple sclerosis: A randomized controlled trial. Mult Scler J. 2019;25(4):610–7.Google Scholar ↗

[refR-6] Pagnini F, Cavalera C, Rovaris M, Mendozzi L, Molinari E, Phillips D, et al. Longitudinal associations between mindfulness and well-being in people with multiple sclerosis. Int J Clin Heal Psychol [Internet]. 2019;19(1):22–30. Available from: http://dx.doi.org/10.1016/j.ijchp.2018.11.003DOI ↗Google Scholar ↗

[refR-7] Agland S, Lydon A, Shaw S, Lea R, Mortimer-Jones S, Lechner-Scott J. Can a stress management programme reduce stress and improve quality of life in people diagnosed with multiple sclerosis? Mult Scler J - Exp Transl Clin. 2018;4(4):205521731881317.Google Scholar ↗

[refR-8] Blankespoor RJ, Schellekens MPJ, Vos SH, Speckens AEM, de Jong BA. The Effectiveness of Mindfulness-Based Stress Reduction on Psychological Distress and Cognitive Functioning in Patients with Multiple Sclerosis: a Pilot Study. Mindfulness (N Y). 2017;8(5):1251–8.Google Scholar ↗

[refR-9] Carletto S, Tesio V, Borghi M, Francone D, Scavelli F, Bertino G, et al. The effectiveness of a body-affective mindfulness intervention for multiple sclerosis patients with depressive symptoms: A randomized controlled clinical trial. Front Psychol. 2017;8(NOV):1–13.Google Scholar ↗

[refR-10] Gilbertson RM, Klatt MD. Mindfulness in motion for people with multiple sclerosis: A feasibility study. Int J MS Care. 2017;19(5):225–31.Google Scholar ↗

[refR-11] Simpson R, Mair FS, Mercer SW. Mindfulness-based stress reduction for people with multiple sclerosis - A feasibility randomised controlled trial. BMC Neurol. 2017;17(1):1–12.Google Scholar ↗

[refR-12] Bogosian A, Hughes A, Norton S, Silber E, Moss-Morris R. Potential treatment mechanisms in a mindfulness-based intervention for people with progressive multiple sclerosis. Br J Health Psychol. 2016;Google Scholar ↗

[refR-13] Carletto S, Borghi M, Francone D, Scavelli F, Bertino G, Cavallo M, et al. The efficacy of a Mindfulness Based Intervention for depressive symptoms in patients with Multiple Sclerosis and their caregivers: Study protocol for a randomized controlled clinical trial. BMC Neurol. 2016;Google Scholar ↗

[refR-14] Nejati S, Rajezi Esfahani S, Rahmani S, Afrookhteh G, Hoveida S. The Effect of Group Mindfulness-based Stress Reduction and Consciousness Yoga Program on Quality of Life and Fatigue Severity in Patients with MS. J Caring Sci [Internet]. 2016;5(4):325–35. Available from: http://dx.doi.org/10.15171/jcs.2016.034DOI ↗Google Scholar ↗

[refR-15] Fleck MP de A. O instrumento de avaliação de qualidade de vida da Organização Mundial da Saúde ( WHOQOL-100 ): características e perspectivas The World Health Organization instrument to evaluate quality of life ( WHOQOL-100 ): characteristics and perspectives. Cien Saude Colet. 2000;5(1):33–8.Google Scholar ↗

[refR-16] Castillo, Letícia N. C.; Leporace, Gustavo; Cardinot, Themis M.; Levy, Roger A.; Oliveira LP. a Importância Dos Questionários Para Avaliação Da Qualidade De Vida. Rev Hosp Univ Pedro Ernesto, UERJ. 2012;11(1):12–7.Google Scholar ↗

[refR-17] I RSF. Propostas pelas Diretrizes Curriculares Proposed for Curriculum Guidelines. 38(2):221–30.Google Scholar ↗

[refR-18] Acesso DE. Política Nacional de Práticas Integrativas e Complementares no SUS.Google Scholar ↗

[refR-19] Eletr R, Garcia S. Metodologia da pesquisa científica: organização estrutural e os desafios para redigir o trabalho de conclusão praça,. 2015;72–87.Google Scholar ↗

[refR-20] Era M. Estudos de Coorte e de Caso-Controle na Era da Medicina Baseada em Evidência. 3.Google Scholar ↗

[refR-21] Tang Y, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Publ Gr [Internet]. 2015;16(4):213–25. Available from: http://dx.doi.org/10.1038/nrn3916DOI ↗Google Scholar ↗

[refR-22] Venasse M, Edwards T, Pilutti LA. Exploring Wellness Interventions in Progressive Multiple Sclerosis: an Evidence-Based Review. Curr Treat Options Neurol. 2018;20(5).Google Scholar ↗

[refR-23] Kabat-Zinn J. Mindfulness-Based Stress Reduction ( Mbsr ): Standards Of Practice Edited and Revised by: Saki F Santorelli. 1996;(February):1–24.Google Scholar ↗

[refR-24] Kabat-zinn J. An Outpatient Program in Behavioral Medicine for Chronic Pain Patients Based on the Practice of Mindfulness Meditation : Results. 1982;Google Scholar ↗

[refR-25] Baer RA. Mindfulness Training as a Clinical Intervention : 2003;(1998):125–43.Google Scholar ↗

[refR-26] Phyo AZZ, Demaneuf T, De Livera AM, Jelinek GA, Brown CR, Marck CH, et al. The efficacy of psychological interventions for managing fatigue in people with multiple sclerosis: A systematic review and meta-analysis. Front Neurol. 2018;9(APR).Google Scholar ↗

[refR-27] Willekens B, Perrotta G, Cras P, Cools N. Into the Moment: Does Mindfulness Affect Biological Pathways in Multiple Sclerosis? Front Behav Neurosci. 2018;12(May):1–9.Google Scholar ↗

[refR-28] Pakenham KI, Mawdsley M, Brown FL, Burton NW, Pakenham KI, Mawdsley M, et al. Rehabilitation Psychology People With Multiple Sclerosis Multiple Sclerosis. 2017;Google Scholar ↗

[refR-29] Lorenz RA, Auerbach S, Nisbet P, Sessanna L, Alanazi N, Lach H, et al. Improving Sleep among Adults with Multiple Sclerosis using Mindfulness plus Sleep Education. 2020;Google Scholar ↗

[refR-30] Turner AP, Knowles LM. Behavioral Interventions in Multiple Sclerosis. 2020;(April):31–5.Google Scholar ↗

[refR-31] Schirda B, Nicholas JA, Prakash RS. Examining trait mindfulness, emotion dysregulation, and quality of life in multiple sclerosis. Heal Psychol. 2015;Google Scholar ↗

[refR-32] Topcu G, Griffiths H, Bale C, Trigg E, Clarke S, Potter K, et al. Psychosocial adjustment to multiple sclerosis diagnosis : A meta-review of systematic reviews. Clin Psychol Rev [Internet]. 2020;82(September):101923. Available from: https://doi.org/10.1016/j.cpr.2020.101923DOI ↗Google Scholar ↗

[refR-33] SPEM. Escala Expandida Do Estado De Incapacidade - Edss. 2014;7–9. Available from: http://www.spem.org/0_content/biblioteca/Dossiers_Tcnicos/51939707-ESCALA-EDSS-ESCLEROSE-MULTIPLA_3.pdfGoogle Scholar ↗