Association of Silent Information Regulator 1 (Sirt1) Gene Polymorphism with the Pathogenesis of Diabetic Nephropathy
Downloads
Introduction: Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes mellitus. Patients with diabetic nephropathy are at a higher risk of morbidity and mortality than those without nephropathy. In this case, early diagnosis and prevention of DM are crucial. SIRT1, which is among the seven members of sirtuins, is recognized as an important element in the pathogenesis of type 2 diabetes, therefore it has several actions in the diabetic nephropathy that will be further discussed in this study. This study will analyse the relationship between SIRT1 gene polymorphism and serum sirt1 in the pathogenesis of diabetic nephropathy.
Aim of the study: evaluation of the association of Silent Information Regulator1 (SIRT1) gene polymorphism and serum SIRT1 protein with type 2 diabetic patients and their role in the pathogenesis of diabetic nephropathy.
Subjects and Methods: This study was carried out on 120 subjects with matched age and sex. They were divided into 3 groups: (Group 1: 40 diabetic nephropathy patients, Group 2: 40 diabetic patients without diabetic nephropathy, Group 3: 40 healthy control subjects ) to discuss the association of sirt1 gene polymorphism and the pathogenesis of diabetic nephropathy.
Results: The mean levels of the serum SIRT1 protein was significantly increasing in the diabetic nephropathy group than the diabetics without diabetic nephropathy and the controls, while it was not significant between the diabetics without DN and the control group.
Conclusion: Basedon this study, SIRT1 gene polymorphism is a significant factor in the development and progression of DN.
Downloads
Kumar A., Singh UK. (2013). Molecular mechanisms in the pathogenesis of diabetic nephropathy: an update. Vascul Pharmacol. 2013 Apr;58(4):259-71. doi: 10.1016/j.vph.2013.01.001. Epub 2013 Jan 11. PMID: 23313806.
Donate-Correa J, Martín-Núñez E, Muros-de-Fuentes M, et al. (2015). Inflammatory cytokines in diabetic nephropathy. J Diabetes Res. 2015;2015:948417. doi: 10.1155/2015/948417. Epub 2015 Feb 15. PMID: 25785280; PMCID: PMC4345080.
Afkarian M, Sachs MC, Kestenbaum B, et al.,(2013). Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013 Feb;24(2):302-8. doi: 10.1681/ASN.2012070718. Epub 2013 Jan 29. PMID: 23362314; PMCID: PMC3559486.
Zhang L, et al. (2016): Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study. J Diabetes Complications. 2016 Jul;30(5):803-10.doi:10.1016/j.jdiacomp.2016.03.020. Epub 2016 Mar 17. PMID: 27068269.
Kume S, Uzu T, Kashiwagi A. et al. (2010): SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications. Endocr Metab Immune Disord Drug Targets; 10: 16-24
Polak-Jonkisz D, Laszki-Szczachor K, Rehan L. et al. (2013): Nephroprotective action of sirtuin 1 (SIRT1). J Physiol Biochem; 69: 957-961
Maeda S, Koya D, Araki S. et al. (2011): Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol; 15: 381-390
Young BA, Maynard C, Boyko EJ., et al., (2003): Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans. Diabetes Care 26 (8):2392–2399
Haraldsson B, Nystrom J, Deen WM, et al., (2008): Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 88 (2):451–487
Gnudi L, Gentile G, Ruggenenti P, et al., (2016): The patient with diabetes mellitus. In: Turner N, Lamiere N, Goldsmith DJ, Wineearls CG, Himmelfarb J, Remuzzi G (eds) Oxford textbook of clinical nephrology, vol 2. Oxford University Press, Oxford, pp 1199–1247
Huang L. and Khardori R. (2017): Pathogenesis of Diabetic Nephropathy. In: Managing Diabetic Nephropathies in Clinical Practice. Adis, Cham. https://doi.org/10.1007/978-3-319-08873-0_2
Amin R, Turner C, van Aken S, et al., (2005): The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study. Kidney Int.;68:1740–9.
Premaratne E, Verma S, Ekinci EI, et al., (2015): The impact of hyperfiltration on the diabetic kidney. Diabetes Metab.;41:5–17.
Singh AK, Mo W, Dunea G, et al., (1998): Effect of glycated proteins on the matrix of glomerular epithelial cells. J Am Soc Nephrol.;9:802–10.
Reidy K, Kang HM, Hostetter T, et al., (2014): Molecular mechanisms of diabetic kidney disease. J Clin Invest. ;124: 2333–40.
Tervaert TW, Mooyaart AL, Amann K, et al., (2010): Pathologic classification of diabetic nephropathy. J Am Soc Nephrol.;21:556–3.
Romagnani P. and Remuzzi G. (2013): Renal progenitors in non-diabetic and diabetic nephropathies. Trends Endocrinol Metab.;24:13–20.
Furuta T, Saito T, Ootaka T, et al. (1993): The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis.;21:480–5.
Nguyen D, Ping F, Mu W, et al., (2006): Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton).;11:226–31.
Yonemoto S, Machiguchi T, Nomura K, et al., (2006): Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus. Clin Exp Nephrol.;10:186–92.
Ha HJ, Yu MR, Choi YJ, et al., (2002): Role of high glucose-induced nuclear factor-kappa B activation in monocyte chemoattractant protein-1 expression by mesangial cells. J Am Soc Nephrol.;13:894–902
Chen JS, Lee HS, Jin JS, et al. (2004): Attenuation of mouse mesangial cell contractility by high glucose and mannitol: Involvement of protein kinase C and focal adhesion kinase. J Biomed Sci.;11:142–51.
Ruiz-Ortega M, Lorenzo O, Ruperez M, et al., (2001): Renin-angiotensin system and renal damage: emerging data on angiotensin II as a proinflammatory mediator. Contrib Nephrol.;135:123–37.
Nakagawa T, Tanabe K, Croker BP, et al., (2011): Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol.;7:36–44.
Rudberg S. and Osterby R. (1997): Decreasing glomerular filtration rate – an indicator of more advanced diabetic glomerulopathy in the early course of microalbuminuria in IDDM adolescents? Nephrol Dial Transplant.;12:1149–54.
Nelson RG, Knowler WC, McCance DR, et al., (1993): Determinants of end-stage renal disease in Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus and proteinuria. Diabetologia.;36:1087–93.
Deckert T, Feldt-Rasmussen B, BorchJohnsen K, et al.,(1989): Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 32(4):219–226
Berhane AM, Weil EJ, Knowler WC, et al., (2011): Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death. Clin J Am Soc Nephrol 6(10):2444–2451
Gnudi L, Coward RJ, Long DA, et al., (2016): Diabetic nephropathy: perspective on novel molecular mechanisms. Trends Endocrinol Metab 27 (11):820–830
Gizem D and Tiago FO. (2013): SIRT1 and SIRT2: emerging targets in neurodegenration. EMBO Mol Med.;5:344 – 352.
Guan, Y., and Hao, C.M. (2015, 10 13): SIRT1 and Kidney Function. Kidney Diseases, 1(4), 258-265.
Haigis MC and Sinclair DA. (2010): Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol.;5:253–295
Wakino S, Hasegawa K, Itoh H, et al., (2015): Sirtuin and metabolic kidney disease. Kidney Int, Epub ahead of print.
Dong Y., Liu, Xiao, et al., (2014): Renal protective effect of sirtuin 1. Journal of Diabetes Research, 2014. Hindawi Publishing Corporation.
Haigis M. C. and Guarente L. P., (2006): “Mammalian sirtuins— emerging roles in physiology, aging, and calorie restriction,”Genes and Development, vol.20, no.21, pp.2913–2921.
Kong L., Wu, H., Zhou W., et al.,(2015, 1 12): Sirtuin 1: A target for kidney diseases. Molecular Medicine, 21, 87-97.
Kitada, M., Kume, S. & Koya, D., et al., (2014): Role of sirtuins in kidney disease. Curr. Opin. Nephrol. Hypertens. 23,
Turkmen k, Karagoz A, Kucuk A, et al., (2014): Sirtuins as novel players in the pathogenesis of diabetes mellitus. World J Diabetes.; 5(6):894- 900
Song YS, Lee SK, Jang YJ, et al., (2013): Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes. Diabetes Res ClinPract. 101: 341-348.
Rahman S and Islam R (2011): Mammalian Sirt1: insights on its biological functions. Cell Commun Signal.; 9: 11.
Gross JL, de Azevedo MJ, Silveiro SP, et al., (2005): Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 28(1):164–176
Coresh J, Selvin E, Stevens LA., et al. (2007): Prevalence of chronic kidney disease in the United States. JAMA; 298: 2038-2047
Gok O, Karaali Z, Ergen A, et al.,(2019 JUN): Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs. J Res Med Sci. 25;24:56. doi: 10.4103/jrms.JRMS_921_18. PMID: 31333735; PMCID: PMC6611179.
Tang, K., Sun M., Shen, J., et al., (2017): Transcriptional Coactivator p300 and Silent Information Regulator 1 (SIRT1) Gene Polymorphism Associated with Diabetic Kidney Disease in a Chinese Cohort. Experimental and Clinical Endocrinology & Diabetes, 125.
Zhao, Y., Wei, J., Hou, X., et al., (2017, 12 1): SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy. Scientific Reports, 7(1)
-
Copyright (c) 2022 Ola Abdelmoneim Elkholy, Gihan Farouk Attia, Wesam Salah, Amal Selim
This work is licensed under a Creative Commons Attribution 4.0 International License.