Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor A Case Report

Vaginal primary malignant melanoma is a rare and very aggressive tumor. It most commonly occurs in
postmenopausal women, with a mean age of 57 years. Our patient is an 70-year-old, postmenopausal
woman presented with a complaint of abnormal vaginal bleeding. On gynecologic examination there was
a pigmented, raised, ulcerated, and irregular lesion 5 x 4.5  cm in the upper third of lateral vaginal wall.
She underwent a wide local excision of the lesion. The histopathology revealed vaginal primary malignant
melanoma and no clear surgical margins. She denied any additional surgical interventions and underwent
to postoperative adjuvant radiotherapy. Follow up 5 months after initial diagnosis revealed no evidence of
local recurrence or distant metastasis. The prognosis of vaginal primary malignant melanoma is very poor
despite treatment modality, because most of the cases are diagnosed at advanced stage. Particularly
patients with no clear surgical margins and tumor size >3 cm needed postoperative adjuvant radiotherapy