Exploring the Antimicrobial Properties potential of Lactobacillus Plantarum Postbiotic Engineering k-016
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Bacteria and their metabolites are shown to be a potential therapeutic agent for cancer treatment. Much attention has been directed to Lactic acid bacteria (LAB) which exhibits several killing mechanisms via invasion and colonization of solid tumors. Discovery of the characteristics of postbiotic metabolites that exert the same probiotic effects has attracted immense attention towards anti-cancer effect. It is known that LAB improves health and composition of microbiota in the gut. Supplementation of LAB is proven to enhance the host immunity and modulation of the immune system to fight diseases including cancers. Lactobacillus plantarum is the LAB species isolated from Malaysian fermented food, Tapai Ubi which capable of producing bioactive metabolic products. In this review, the properties will be discussed including anti-microbial, anti-cancer and immunomodulatory effects. Overall, it would be beneficial to discover the potential effects of UL4-PPM to possibly serve as an alternative treatment for cancer.
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Siegel R, Miller K, Jemal A. Cancer statistics, 2017 CA: A Cancer Journal for Clinicians. 2017; 67(1): 7–30.
Hassan MRA, Ismail I, Suan MAM, Ahmad F, Khazim WKW, Othman Z, et al. Incidence and mortality rates of colorectal cancer in Malaysia. Epidemiology and Health. 2016;38.
Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RG, Barzi A, et al. Colorectal cancer statistics, 2017. CA: A Cancer Journal for Clinicians. 2017;67(3):177-193.
Sung J, Ng S, Chan F, Chiu H, Kim H, Matsuda T, et al. An updated Asia Pacific Consensus Recommendations on colorectal cancer screening. Gut. 2015;64(1):121-32.
Singh B, Mukesh M, Sodhi M. Nutrigenomics, metabolomics and metabonomics: emerging faces of molecular genomics and nutrition. Metabolomics: Metabolites, Metabonomics and Analytical Technologies Hauppauge, NY: Nova Science Publishers, Inc. 2011:201-13.
Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. Nature Reviews Immunology. 2012;12(10):728-34.
Licciardi PV, Wong S-S, Tang ML, Karagiannis TC. Epigenome targeting by probiotic metabolites. Gut pathogens. 2010;2(1):24.
Oelschlaeger TA. Mechanisms of probiotic actions–a review. International Journal of Medical Microbiology. 2010;300(1):57-62.
Tsilingiri K, Barbosa T, Penna G, Caprioli F, Sonzogni A, Viale G, et al. Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut. 2012:gutjnl-2011-300971.
Thanh N, Loh TC, Foo HL, Hair-Bejo M, Azhar
B. Effects of feeding metabolite combinations produced by Lactobacillus plantarum on growth performance, faecal microbial population, small intestine villus height and faecal volatile fatty acids in broilers. British poultry science. 2009;50(3):298- 306.
Kareem KY, Loh TC, Foo HL, Akit H, Samsudin AA. Effects of dietary postbiotic and inulin on growth performance, IGF1 and GHR mRNA expression, faecal microbiota and volatile fatty acids in broilers. BMC Veterinary Research. 2016;12(1):163.
Loh T, Chong S, Foo H, Law F. Effects on growth performance, faecal microflora and plasma cholesterol after supplementation of spray-dried metabolite to postweaning rats. Czech Journal Animal Science. 2009;54(1):10-6.
Kumar M, Nagpal R, Verma V, Kumar A, Kaur N, Hemalatha R, et al. Probiotic metabolites as epigenetic targets in the prevention of colon cancer. Nutrition reviews. 2013;71(1):23-34.
O’sullivan L, Ross R, Hill C. Potential of bacteriocin- producing lactic acid bacteria for improvements in food safety and quality. Biochimie. 2002;84(5):593- 604.
Cornut G, Fortin C, Soulières D. Antineoplastic properties of bacteriocins: revisiting potential active agents. American journal of clinical oncology. 2008;31(4):399-404.
Foo H, Loh T, Lai P, Lim Y, Kufli C, Rusul G. Effects of adding Lactobacillus plantarum I-UL4 metabolites in drinking water of rats. Pakistan Journal of Nutrition. 2003;2(5):283-8.
Loh TC, Thanh NT, Foo HL, HAIR◻BEJO M,
Azhar BK. Feeding of different levels of metabolite combinations produced by Lactobacillus plantarum on growth performance, fecal microflora, volatile fatty acids and villi height in broilers. Animal Science Journal. 2010;81(2):205-14.
del Carmen S, de LeBlanc AdM, Levit R, Azevedo V, Langella P, Bermúdez-Humarán LG, et al. Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. International Immunopharmacology. 2017;42:122-9.
Chang C-K, Wang S-C, Chiu C-K, Chen S-Y, Chen Z-T, Duh P-D. Effect of lactic acid bacteria isolated from fermented mustard on immunopotentiating activity. Asian Pacific Journal of Tropical Biomedicine. 2015;5(4):281-6.
Kwak S-H, Cho Y-M, Noh G-M, Om A-S. Cancer preventive potential of kimchi lactic acid bacteria (Weissella cibaria, Lactobacillus plantarum). Journal of cancer prevention. 2014;19(4):253-8.
Loh T, Harun H, Foo H, Law F. Effects Of Feeding Spraydried Metabolite Of Lactococcus Lactis Subsp. Lactis-RW18 In Postweaning Rats. International Journal of Probiotics and Prebiotics. 2008;3(1):1.
Modler HW, McKellar R, Yaguchi M. Bifidobacteria and bifidogenic factors. Canadian Institute of Food Science and Technology Journal. 1990;23(1):29- 41.
Chesson A. Phasing out antibiotic feed additives in the EU: worldwide relevance for animal food production. Barug, D, DeJong, J, Kies, AK, Verstegen, MWA, Antimicrobial Growth Promoters: Where Do We Go from Here Wageningen Academic Publications, Wageningen. 2006:69-81.
Miles R, Butcher G, Henry P, Littell R. Effect of antibiotic growth promoters on broiler performance, intestinal growth parameters, and quantitative morphology. Poultry Science. 2006;85(3):476-85.
Tannock GW, Fuller R, Smith S, Hall M. Plasmid profiling of members of the family Enterobacteriaceae, lactobacilli, and bifidobacteria to study the transmission of bacteria from mother to infant. Journal of Clinical Microbiology. 1990;28(6):1225-8.
Fernandes CF, Shahani KM. Anticarcinogenic and immunological properties of dietary lactobacilli. Journal of Food Protection®. 1990;53(8):704-10.
Shaikh F, Abhinand P, Ragunath P. Identification & Characterization of lactobacillus salavarius bacteriocins and its relevance in cancer therapeutics. Bioinformation. 2012;8(13):589.
Govindan SV, Griffiths GL, Hansen HJ, Horak ID, Goldenberg DM. Cancer therapy with radiolabeled
and drug/toxin-conjugated antibodies. Technology in Cancer Research & Treatment. 2005;4(4):375- 91.
Johannes L, Decaudin D. Protein toxins: intracellular trafficking for targeted therapy. Gene Therapy. 2005;12(18):1360-8.
Lancaster LE, Wintermeyer W, Rodnina MV. Colicins and their potential in cancer treatment. Blood Cells, Molecules, and Diseases. 2007;38(1):15-8.
Tan HK, Foo HL, Loh TC, Alitheen M, Banu N, Abdul Rahim R. Cytotoxic effect of proteinaceous postbiotic metabolites produced by Lactobacillus plantarum I-UL4 cultivated in different media composition on MCF-7 breast cancer cell. Malaysian Journal of Microbiology. 2015;11(2):207-14.
Liong M-T. Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence. International Journal of Molecular Sciences. 2008;9(5):854-63.
Hirayama K, Rafter J. The role of probiotic bacteria in cancer prevention. Microbes and Infection. 2000;2(6):681-6.
Yamazaki K, Tsunoda A, Sibusawa M, Tsunoda Y, Kusano M, Fukuchi K, et al. The effect of an oral administration of Lactobacillus casei strain shirota on azoxymethane-induced colonic aberrant crypt foci and colon cancer in the rat. Oncology Reports. 2000;7(5):977-82.
Kumar M, Kumar A, Nagpal R, Mohania D, Behare P, Verma V, et al. Cancer-preventing attributes of probiotics: an update. International Journal of Food Sciences and Nutrition. 2010;61(5):473-96.
Lee DK, Jang S, Kim MJ, Kim JH, Chung MJ, Kim KJ, et al. Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines. BMC Cancer. 2008;8(1):310.
Ma EL, Choi YJ, Choi J, Pothoulakis C, Rhee SH, Im E. The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. International Journal of Cancer. 2010;127(4):780- 90.
Zakuan NM. Potential Anti-cancer Properties of Bacteriocin UL4 from Lactobacillus Plantarum in Rats Induced with Colon Cancer: Universiti Putra Malaysia; 2011.
Guandalini S. Use of Lactobacillus-GG in paediatric Crohn’s disease. Digestive and Liver Disease. 2002;34:S63-S5.
Dimitrovski D, Cencič A, Winkelhausen E, Langerholc T. Lactobacillus plantarum extracellular metabolites: In vitro assessment of probiotic effects on normal and cancerogenic human cells. International Dairy Journal. 2014;39(2):293-300.
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