Co-occurrence of Kimura's Disease and Keratoconus: A Case Report

Saad Mutlaq Alosaimi; Hala M Nassim Ali; Askar K Alshaibani

doi:10.18535/ijsrm/v12i12.mp01

Abstract

Kimura disease, often referred to as eosinophilic granuloma, is an uncommon and long-lasting condition that is mostly seen in people of Asian ancestry. Early signs include increased levels of IgE in the blood, nodules under the skin, and swelling of the lymph nodes. Keratoconus is a disorder where both corneas get steeper and vision is reduced. It is not genetically connected to Kimura disease, although both illnesses are more common among Asian people. Performing a histopathological investigation of the mass is essential in order to get an accurate diagnosis. This case reports a 24-year-old male patient living in Saudi Arabia who had a growth on his face that extended above and below the medial canthus of his eye. The patient also had a gradual decrease in vision in both eyes. The patient received a comprehensive biopsy procedure and topographical examinations. The biopsy findings indicated the presence of angiolymphoid hyperplasia with eosinophilia, and no accompanying lymphadenopathy was seen. The diagnosis of Keratoconus was verified by the examination of the topography. Considering these results, the main therapeutic option is surgical removal of the tumor. This case report offers valuable insights into the diagnostic criteria, differential diagnosis, and management of Kimura disease, specifically in relation to keratoconus. Additionally, it contributes to the existing literature by presenting the first documented case of Kimura disease with concurrent keratoconus.

Keywords

Kimura diseaseEosinophilic granulomaEyelid massUnilateral Keratoconuslymphatic vessels proliferation

References

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Kumar V, Mittal N, Huang Y, et al.: A case series of Kimura’s disease: a diagnostic challenge. 2018, 9:207-211.Google Scholar ↗
Glibbery N, Muscat K, Cascarini LJJoscr: Kimura’s disease of the parotid gland with cutaneous features in a Caucasian female patient. 2018, 2018:rjy067.Google Scholar ↗
Sun QF, Xu DZ, Pan SH, et al.: Kimura disease: review of the literature. 2008, 38:668-672.Google Scholar ↗
Kim HJCMJ: Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz's disease. 1937, 23:699-670.Google Scholar ↗
Kimura TJTSPJ: On the unusual granulations combined with hyperplastic changes of lymphatic tissue. 1948, 37:179-180.Google Scholar ↗
Ye P, Ma D-Q, Yu G-Y, et al.: Comparison of the efficacy of different treatment modalities for Kimura's disease. 2017, 46:350-354.Google Scholar ↗
Tseng CF, Lin HC, Huang SC, et al.: Kimura's disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol. 2005, 262:8-10. 10.1007/s00405-003-0677-9DOI ↗Google Scholar ↗
Brown MD, Potter JW: Floppy eyelid syndrome: a case report and clinical review. J Am Optom Assoc. 1992, 63:309-314.Google Scholar ↗
Negris R: Floppy eyelid syndrome associated with keratoconus. J Am Optom Assoc. 1992, 63:316-319.Google Scholar ↗
Rathi VM, Mandathara PS, Dumpati S: Contact lens in keratoconus. Indian J Ophthalmol. 2013, 61:410-415. 10.4103/0301-4738.116066DOI ↗Google Scholar ↗
Karseras AG, Ruben M: Aetiology of keratoconus. Br J Ophthalmol. 1976, 60:522-525. 10.1136/bjo.60.7.522DOI ↗Google Scholar ↗
Donnenfeld ED, Perry HD, Gibralter RP, et al.: Keratoconus associated with floppy eyelid syndrome. Ophthalmology. 1991, 98:1674-1678. 10.1016/s0161-6420(91)32070-0DOI ↗Google Scholar ↗
Nakai Y: [Case of eosinophilic granuloma in the orbit]. Ganka. 1966, 8:429-431.Google Scholar ↗
Li J, Ge X, Ma J, et al.: Kimura's disease of the lacrimal gland mimicking IgG4-related orbital disease. BMC Ophthalmol. 2014, 14:158. 10.1186/1471-2415-14-158DOI ↗Google Scholar ↗
Goncalves AC, Moritz RB, Aldred VL, et al.: Bilateral extraocular muscles enlargement from Kimura's disease of the orbit. Indian J Ophthalmol. 2016, 64:538-540. 10.4103/0301-4738.118424DOI ↗Google Scholar ↗
Francis IL, Ramalingam M, Ali NAM, et al.: Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. Ophthalmic Plast Reconstr Surg. 2017, 33:S45-s47. 10.1097/iop.0000000000000480DOI ↗Google Scholar ↗
Chakraborti C, Saha AK, Bhattacharjee A, et al.: Kimura's disease involving bilateral lacrimal glands and extraocular muscles along with ipsilateral face: A unique case report. Indian J Ophthalmol. 2019, 67:2107-2109. 10.4103/ijo.IJO_810_19DOI ↗Google Scholar ↗
Agrawal S, Sen S, Sabu S, et al.: Bilateral orbital Kimura's disease: A case report and brief review of literature. Indian J Ophthalmol. 2022, 70:2737-2738. 10.4103/ijo.IJO_2648_21DOI ↗Google Scholar ↗

[refR-1] Sorbello M, Laudini A, Morello G, et al.: Anaesthesiological implications of Kimura's disease: a case report. J Med Case Rep. 2009, 3:7316. 10.4076/1752-1947-3-7316DOI ↗Google Scholar ↗

[refR-2] Kumar V, Mittal N, Huang Y, et al.: A case series of Kimura’s disease: a diagnostic challenge. 2018, 9:207-211.Google Scholar ↗

[refR-3] Glibbery N, Muscat K, Cascarini LJJoscr: Kimura’s disease of the parotid gland with cutaneous features in a Caucasian female patient. 2018, 2018:rjy067.Google Scholar ↗

[refR-4] Sun QF, Xu DZ, Pan SH, et al.: Kimura disease: review of the literature. 2008, 38:668-672.Google Scholar ↗

[refR-5] Kim HJCMJ: Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz's disease. 1937, 23:699-670.Google Scholar ↗

[refR-6] Kimura TJTSPJ: On the unusual granulations combined with hyperplastic changes of lymphatic tissue. 1948, 37:179-180.Google Scholar ↗

[refR-7] Ye P, Ma D-Q, Yu G-Y, et al.: Comparison of the efficacy of different treatment modalities for Kimura's disease. 2017, 46:350-354.Google Scholar ↗

[refR-8] Tseng CF, Lin HC, Huang SC, et al.: Kimura's disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol. 2005, 262:8-10. 10.1007/s00405-003-0677-9DOI ↗Google Scholar ↗

[refR-9] Brown MD, Potter JW: Floppy eyelid syndrome: a case report and clinical review. J Am Optom Assoc. 1992, 63:309-314.Google Scholar ↗

[refR-10] Negris R: Floppy eyelid syndrome associated with keratoconus. J Am Optom Assoc. 1992, 63:316-319.Google Scholar ↗

[refR-11] Rathi VM, Mandathara PS, Dumpati S: Contact lens in keratoconus. Indian J Ophthalmol. 2013, 61:410-415. 10.4103/0301-4738.116066DOI ↗Google Scholar ↗

[refR-12] Karseras AG, Ruben M: Aetiology of keratoconus. Br J Ophthalmol. 1976, 60:522-525. 10.1136/bjo.60.7.522DOI ↗Google Scholar ↗

[refR-13] Donnenfeld ED, Perry HD, Gibralter RP, et al.: Keratoconus associated with floppy eyelid syndrome. Ophthalmology. 1991, 98:1674-1678. 10.1016/s0161-6420(91)32070-0DOI ↗Google Scholar ↗

[refR-14] Nakai Y: [Case of eosinophilic granuloma in the orbit]. Ganka. 1966, 8:429-431.Google Scholar ↗

[refR-15] Li J, Ge X, Ma J, et al.: Kimura's disease of the lacrimal gland mimicking IgG4-related orbital disease. BMC Ophthalmol. 2014, 14:158. 10.1186/1471-2415-14-158DOI ↗Google Scholar ↗

[refR-16] Goncalves AC, Moritz RB, Aldred VL, et al.: Bilateral extraocular muscles enlargement from Kimura's disease of the orbit. Indian J Ophthalmol. 2016, 64:538-540. 10.4103/0301-4738.118424DOI ↗Google Scholar ↗

[refR-17] Francis IL, Ramalingam M, Ali NAM, et al.: Recurrent Kimura Disease of the Inner Canthus With No Lymphadenopathy. Ophthalmic Plast Reconstr Surg. 2017, 33:S45-s47. 10.1097/iop.0000000000000480DOI ↗Google Scholar ↗

[refR-18] Chakraborti C, Saha AK, Bhattacharjee A, et al.: Kimura's disease involving bilateral lacrimal glands and extraocular muscles along with ipsilateral face: A unique case report. Indian J Ophthalmol. 2019, 67:2107-2109. 10.4103/ijo.IJO_810_19DOI ↗Google Scholar ↗

[refR-19] Agrawal S, Sen S, Sabu S, et al.: Bilateral orbital Kimura's disease: A case report and brief review of literature. Indian J Ophthalmol. 2022, 70:2737-2738. 10.4103/ijo.IJO_2648_21DOI ↗Google Scholar ↗