An Observational Cross Sectional Study Of Serum Anti-Mullerian Hormone In PCOS Infertile Women

OBJECTIVE: To evaluate the role of serum Anti-Mullerian Hormone in PCOS infertile women.

METHOD: A total of 64 Polycystic ovary syndrome  infertile women of 18-35 years age, according to Rotterdam Criteria (2003) were observed for role of serum Anti-Mullerian Hormone in PCOS infertile women. Serum levels of  LH, FSH, testosterone, fasting insulin and AMH were measured in the early follicular phase (day 3–4) of natural cycle or progestin-induced withdrawal bleeding (in PCOS); together with TVS for detection of the number of small follicles (<10 mm) and calculation of ovarian volume.

RESULTS: Serum AMH was significantly higher in the PCOS infertile women. 61 patients (95.3 percent) have serum AMH level >10ng/ml.59 patients (92.2 percent) have number of follicles >12 (size <10mm) and higher ovarian volume. Serum Testosterone level >70 pg/dl in 27 patients (42.2 percent), LH/FSH ratio >2 in 38 patients (59.4 percent),34 (53.1 percent) patients have insulin resistance. Acne in 53(82.8 percent),Hirsutism in 42 (65.6 percent), Acanthosis nigricans in 8 (12.5 percent) patients, irregular menstrual cycle & oligo or amenorrhoea in 58 (90.6 percent) patients and BMI >25kg/m² in 41(64 percent) patients.

CONCLUSION: Serum AMH is a good marker of Ovarian  reserve. Serum   AMH level two or three times the normal amount, is a good indicator of PCOS and infertility. It can be used as an alternative  diagnostic criteria for PCOS patients and  may be used as a marker for the extent or severity of the disease in PCOS infertile female.AMH positively correlate to LH, LH/FSH, and number of follicles <10mm and ovarian volume. No correlation between AMH and age, BMI and  fasting insulin level  in PCOS infertile women