Effects of Aqueous Ethanolic Extract of the leaves of Guiera senegalensis J.F. Gmel (Combretaceae) on Liver Function in Wister Strain Albino Rats

The effects of different doses of aqueous ethanolic extract of the leaves of Guiera senegalensis on liver function test of wister strain albino rats were investigated at high doses of 1000mg/kg and 2000mg/kg which showed high toxicity with some clinical signs but at lower doses of 100mg/kg, 150mg/kg and 200mg/kg, showed little or no effects on the liver function tests (AST, ALT, TP, ALK-PH, and ALB). Of these only ALK-PH showed significant increase (P<0.05) as the dose increases when compared with the control and total protein at only 200mg/kg. The result of these studies showed that G. Senegalensis at lower doses is not harmful to the liver and therefore can be exploited as it is served in the treatments of some illnesses.>