Comparative Evaluation Of Anticancer Potential Of Moringaoleifera, Ganodermalucidumand Silver Nanoparticles Against Breast And Liver Cancer Cell Lines And Related Pro And Anti Apoptotic Genes Profile

The present work aimed to evaluate the anticancer potentials concerning the cytotoxicity and antiproliferative activity of L-amino acid Oxidase (LAAO) ,MoringaOleifera(MO) Methanol (MLM) and water extracts (MLW), Ganodermalucidum(GL), extracts as a natural products and Silver nanoparticles (AgNP) as well. Cytotoxic effect of test extracts on both breast (MCF-7) and liver(HEPG-2) cancer cell lines varied according to test materials and could be arranged in the order of LAAO > MLM>AgNP> GL>MLW. Also, (MCF7) cell line was more sensitive to test materials compared with (HEPG2) cell line. Regarding the genotoxicity it was found that Bcl2 and survivineand caspase -3 as antiapoptotic genes were significantly down regulated and P53 as proapoptotic genes was significantly up regulated in both cell lines