Can Oxidative Stress Induced by Obstructive Jaundice be Improved by Iloprost? An Experimental Study in Rats

https://doi.org/10.18535/ijsrm/v7i3.mp01
Antioxidants, bile duct ligation, experimental study, iloprost, obstructive jaundice, oxidative stress.

Authors

  • Onur Bayraktar T.C. Istanbul Bilim University, School of Medicine Department of General Surgery, Istanbul-Turkey, Türkiye
  • Barış Bayraktar Konak Hospital, Department of General Surgery, Gebze, Kocaeli, Türkiye
  • Ilknur Erenler T.C. Istanbul Bilim University, School of Medicine Department of General Surgery, Istanbul-Turkey, Türkiye
Vol. 7 No. 03 (2019)
Medical Sciences and Pharmacy
March 2, 2019

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Background/Aims: Iloprost is a synthetic analogue of epoprostenol which is synthesized by endotelial cells from arachidonic acid. We aimed to evaluate presumed hepatoprotective and antioxidant effects of iloprost in experimentally created obstructive jaundice in rats.

Materials and Methods: Thirty-two adult male Wistar albino rats were randomly divided into four groups: sham group (S) (n=8); after sham operation, iloprost administered (SI) group (n = 8); obstructive jaundice (OJ) group (n=8); iloprost administered and obstructive jaundice group (OJI) (n=8). The rats were sacrified ten days after the induction of obstructive jaundice. Blood levels of isoprostane, protein carbonyl, lipid hydroperoxide and 8-hydroxy-2-deoxyguanosine (8-OHdG) were measured.

Results: Levels of the oxidative stress products including protein carbonyl [mean, (40.46 versus 24.7 nmol/ml, p=0.005)], lipid hydroperoxide [mean, (5.11 versus 1.85 Mmol/ml,p=0.001)] and 8-OHdG[mean, (1.53 versus 1.13 ng/ml, p=0.03)] in the OJI group were significantly lower than the OJ group.

Conclusion: Iloprost supports antioxidant activity in obstructive jaundice without causing further liver damage in rats.