The Effect of Hypertension on the Risk of Premature Birth: Meta Analysis with Binary Data

Rizky Nur'aini; Andika Putri Ratnasari

doi:10.18535/ijsrm/v12i06.m01

Abstract

Hypertension in pregnancy is a condition where systolic blood pressure increases to more than 140 mmHg and diastolic more than 90 mmHg. Apart from endangering the mother, hypertension is also dangerous for the fetus. We conducted a meta-analysis of articles on the risk of premature birth in pregnant women with hypertension. The research method was carried out by searching for scientific articles in the PubMed and ScienceDirect databases to see if they contained control cases/cohorts of the influence of hypertension on premature birth with N>200. From the search results, 8 eligible journals were selected, namely those containing the relevant independent variable hypertension. The results show that the risk of premature birth is influenced by pregnant women who experience hypertension = 3.971 (95% CI, 2.567; 6.144) with a random effect model because high heterogeneity was detected (I² = 98.992%). This shows that hypertension experienced by pregnant women can increase the risk of premature birth by 4 times. Hopefully, these results can improve health policies that enable more appropriate treatment, and for pregnant women to carry out routine early examinations and maintain nutritional intake and a healthy lifestyle.

Keywords

Hypertensionpremature birthmeta-analysis

References

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Chen DG (Din), Peace KE. Applied Meta-Analysis with R. Chapman and Hall/CRC; 2013.Google Scholar ↗
Borenstein M, Hedges L V., Higgins JPT, Rothstein HR. Introduction to Meta‐Analysis. Wiley; 2009.Google Scholar ↗
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Yang CC, Tang PL, Liu PY, Huang WC, Chen YY, Wang HP, Chang JT, Lin LT. Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk. Medicine. 2018 Aug;97(31):e11739.Google Scholar ↗
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[refR-1] Khosravi S, Dabiran S, Lotfi M, Asnavandy M. Study of the Prevalence of Hypertension and Complications of Hypertensive Disorders in Pregnancy. Open J Prev Med. 2014;04(11):860–7.Google Scholar ↗

[refR-2] Chen DG (Din), Peace KE. Applied Meta-Analysis with R. Chapman and Hall/CRC; 2013.Google Scholar ↗

[refR-3] Borenstein M, Hedges L V., Higgins JPT, Rothstein HR. Introduction to Meta‐Analysis. Wiley; 2009.Google Scholar ↗

[refR-4] Jiang M, Mishu MM, Lu D, Yin X. A case control study of risk factors and neonatal outcomes of preterm birth. Taiwan J Obstet Gynecol. 2018 Dec;57(6):814–8.Google Scholar ↗

[refR-5] Yang CC, Tang PL, Liu PY, Huang WC, Chen YY, Wang HP, Chang JT, Lin LT. Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk. Medicine. 2018 Aug;97(31):e11739.Google Scholar ↗

[refR-6] Vieira ACF, Alves CMC, Rodrigues VP, Ribeiro CCC, Gomes-Filho IS, Lopes FF. Oral, systemic and socioeconomic factors associated with preterm birth. Women and Birth. 2019 Feb;32(1):e12–6.Google Scholar ↗

[refR-7] Stern JE, Liu C ling, Hwang SS, Dukhovny D, Diop H, Cabral H. Contributions to prematurity of maternal health conditions, subfertility, and assisted reproductive technology. Fertil Steril. 2020 Oct;114(4):828–36.Google Scholar ↗

[refR-8] Rohlfing AB, Nah G, Ryckman KK, Snyder BD, Kasarek D, Paynter RA, Feuer SK, Jelliffe-Pawlowski L, Parikh NI. Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case–control study. BMJ Open. 2020 Jun 3;10(6):e034145.Google Scholar ↗

[refR-9] Mekuriyaw AM, Mihret MS, Yismaw AE. Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study. Int J Pediatr. 2020 Jan 10;2020:1–8.Google Scholar ↗

[refR-10] Wakeyo D, Addisu Y, Mareg M. Determinants of Preterm Birth among Mothers Who Gave Birth in Dilla University Referral Hospital, Southern Ethiopia: A Case-Control Study. Biomed Res Int. 2020 Dec 15;2020:1–7.Google Scholar ↗

[refR-11] Gejo NG, W/mariam MT, Kebede BA, Abdo RA, Anshebo AA, Halil HM, Woldu BF, Katiso NA. Factors associated with preterm birth at Wachemo University Nigist Eleni Mohammed memorial hospital, southern Ethiopia: case-control study. BMC Pregnancy Childbirth. 2021 Dec 7;21(1):35.Google Scholar ↗